PRECLINICAL BLOOD CHEMISTRY SAFETY PROFILE STUDIES OF �??ROHITAKARISTA�?� ON THE KIDNEY FUNCTION AFTER CHRONIC ADMINISTRATION TO MALE SPRAGUE-DAWLEY RATS

Md. Arif Hasan, Md. Rakib Hasan*, Mohammad Jashim Uddin, Gulshanara Begum, Nawfel Abdullah, Md. Moklesur Rahman Sarker, Mohammed Motaher Hossain Chowdhury and M. S. K. Choudhuri

Rohitakarista (RHT) is an Ayurvedic preparation used as a traditional medicine in the treatment of splenomegaly. To find out the effect of chronic administration of RHT on serum blood chemistry profile, it was administered chronically to the male Sprague-Dawley rats at a dose of 40 ml/kg for 28 days. In this study, the albumin content was decreased (9.17 %) in RHT treated male rats and it was statistically significant (p=0.047), the globulin content was highly significantly (p=0.012) increased (53.10 %) as a result the decrease (43.18%) in the Albumin / Globulin (A/G) ratio was statistically highly significantly different from their corresponding control values (p=0.005). There were a statistically very highly significant (p=0.001) decrease of blood urea nitrogen (BUN) level (23.97%) and BUN/Creatinine ratio (21.62 %). It was observed that there was a 15.0% decrease in serum uric acid content of RHT treated male rats in comparison to their control male rats which was also statistically significant (p=0.049).