PRECLINICAL LIPID PROFILE STUDIES OF AN AYURVEDIC PREPARATION �??SARAGUNA BALIJARITA MAKARADHVAJA�?� USED AS ANTIPYRETIC

Md. Ashraful Alam, Shahnaz Jalil, Fariha Tasnim, Nahida Akhter, Mohsina Mukti, Md. Rakib Hasan*, Satchit Neupane and MSK Choudhuri

Saraguna Balijarita Makaradhvaja (SBM) is an Ayurvedic preparation used in traditional medicine as an antipyretic in the rural population. We were eager to know the effect of chronic administration of SBM on the lipid profile test. To find out the effect of chronic administration of SBM on the lipid profile, it was administered chronically to the male Sprague-Dawley rats at a dose of 400 mg/Kg. After 28 days of chronic administration of the SBM preparation, the following effects on the lipid profile were noted. There was a statistical significant increase in LDL and Non-HDL Cholesterol (p=0.01). A very highly significant (p=0.001) decrease was noticed in HDL-C level; thus leading to a statistically very highly significant (p=0.001) increase in Cardiac Risk Ratio (CRR) (TC/HDL-C), Castelli’s Risk Index-II (CRI-II) (HDL C/LDL-C) and Atherogenic Coefficient (AC) [(TC/HDLC)/ HDL-C)]. No significant change was found in case of TG, TC, VLDL and Atherogenic Index of Plasma (AIP) (log (TG/HDL-C)).