SCREENING OF PHYTOCHEMICAL AND ANTIPROLIFARATION OF CELL GROWTH LAGENARIA SICERARIA STAND. FRUIT BY PHYTOTOXIC BIOASSAY MODELS

Sarang Sunil Mahamuni, Suresh Ganpati Killedar and Harinath Nivrutti More

Cancer is one of the leading causes of mortality worldwide. Many of the Cucurbitaceae plants possess antitumor activity on the traditional use. The present study was carried out to evaluate the anticancer activity of extracts Lagenaria siceraria Standley Fruit. This fruit has the antioxidant activity so the plant may have anticancer activity. Preliminary phytochemical tests of successive extraction of Lagenaria siceraria Standely Fruit powder had performed to find out the different chemical moieties. Preliminary anticancer screening by exposure of different extracts Phytotoxic Bioassay model was carried out to find out the lead extract which shows the promising cell growth inhibitory activity. Cereals Moth seeds were selected for the Phytotoxic Bioassay which shows the phytotoxicity that compared with standard antimitotic drug (colchicine). n-Butanol extract of Lagenaria siceraria Standley Fruit powder shows the promising anticancer activity or cytotoxicity, so that it is selected as a lead extract. Further isolation of active moiety from n-Butanol extract for anticancer activity by chromatographic techniques is completed.