Abstract
STATISTICAL OPTIMIZATION OF KETOPROFEN TABLETS COMPRESSION COATED WITH ASSAM BORA RICE STARCH/ETHYL CELLULOSE MIXTURE FOR COLONIC DRUG DELIVERY
Nirmala Devi*, Manju Sharma
The aim of this work was to prepare and optimise the ketoprofen colon targeted compression coated tablet using mixture of Assam bora rice starch and ethyl cellulose as coating agent. 32 factorial designs was used to study the effect of ethyl cellulose content (X1) and coating level (X2) on the release of ketoprofen from colon targeted tablet. Dissolution study was performed in pH1.2 for 2 hr, pH 7.4 for 3 hr and goat caecal medium for 5 hr. Multiple linear regression analysis was used for generation of polynomial equation and optimization of formulation. The optimized formulation consisted of ethyl cellulose (31.39 %) and coating level (416.8 mg) provided a release profile that is closed to estimated values.
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