Abstract
SYNTHESIS AND BIOLOGICAL EVALUATION OF 1-SUBSTITUTED IMIDAZOLE DERIVATIVES
Prasanthy G, Venkata Ramana K, Koti Reddy V, Nirmala K, Ramesh Kumar N
In the present study, a new series of 1-substituted imidazole derivatives were synthesized taking different anilines and sulfonamides as substitutions. The chemical structures were confirmed by means of IR, 1H-NMR and Mass spectral data. The compounds were screened for their anticancer and antimicrobial activities. N-(3-chloro-4-fluorophenyl)-4-(1H-imidazol-1-yl)benzamide exhibited highest activity against cervical cancer. 4-(1H-imidazol-1-yl)-N-(4-(N-(5-methylisoxazol-4-yl) sulfamoyl) phenyl) benzamide showed good antifungal activity. 4-(1H-imidazol-1-yl)-N-(4-(N-thiazol-4-ylsulfamoyl) phenyl) benzamide showed good antibacterial activity.
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