Abstract
SYNTHESIS AND EVALUATION OF A MUTUAL PRODRUG
Asif Husain, Aftab Ahmad, Shah Alam Khan, Mohammad Sarafroz
The aim of this study has been to synthesize a useful drug, which may act with effectiveness both on the gram-positive and gram-negative bacteria (broad-spectrum). An amide-based mutual prodrug (3) was synthesized by condensing sulfadiazine with nalidixic acid, and evaluated for in-vitro antibacterial activity with significant results. Hydrolysis kinetics of the mutual prodrug were also studied in acidic and basic buffers.
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