SYNTHESIS AND EVALUATUION OF SOME NOVEL MERCAPTOBENZIMIDAZOLE DERIVATIVES

Pratik P Maske*, Sunil Nalavade, Satheesh Patil

A new class of potentially biological active mercaptobezimidazole derivatives containing Benzimidazole moiety has been synthesized. New series of acids and aldehyde substituted benzimidazoles A6–10 were synthesized by the Schiff’s Base method. Synthesized compounds A6–10 were confirmed by IR, ¹H NMR, Mass and elemental analysis and further screened for antimicrobial activity and antiprotozoal activity. The in vitro antibacterial and antifungal potential of the products were also determined using bacterial strains.( E.coli ATCC 25922, S.Aureus ATCC 29213, P.aeruginosa MTCC741, C.albicansATCC 9025, A.nigerATCC 1015) The synthesized compounds exhibited significant antimicrobial & antiprotozoal activities compared to standard compounds.