Toxicological studies of an ayurvedic medicine Yogendra Ras used in epilepsy

Mustari Hossain, Md. Rakib Hasan*, Majana Khalil, Maksud Hasan Binoy, Md. Mamun Sikder, Tahmina Akter Sony, Afaz Uddin, M. S. K. Choudhuri

Yogendra Ras (YR) is an ayurvedic preparation used as a traditional medicine in the treatment of epilepsy. To find out the toxicological characteristic of YR, it was administered chronically to the Sprague-Dawley rats at a dose of 40 mg/kg for 28 days. After 28 days chronic administration of the YR preparation, the following toxicological changes were noted. All throughout the experimental period, the YR treated animals were always maintaining negligible changes in overall body weight. There is a statistically very highly significant (p=0.001; 25.50% decrease) decrease in the absolute weight of the male rat liver and a highly significant (p=0.006; 23.53% decrease) decrease in the relative percent weight of the male rat liver. There is also a statistically highly significant (p=0.002; 18.90% decrease) decrease in the absolute weight of the male rat kidney and a statistically significant (p=0.015; 16.69% decrease) decrease in the relative percent weight of the kidney. There is a statistically significant decrease in the absolute weight of the male rat spleen (p=0.017; 31.10% decrease) and the relative percent weight of the male rat spleen (p=0.021; 30.48 % decrease).